Review on the Biocompatibility and Bioactivity of Forsterite: In Vitro and In Vivo Studies

Alexandra AVRAM¹, Aurora MOCANU¹, Gheorghe TOMOAIA^2,3,

Maria TOMOAIA-COTISEL^1,3

¹Babes-Bolyai University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering, Research Centre of Physical Chemistry, 11 Arany Janos Str., RO-400028, Cluj-Napoca, Romania

²Department of Orthopedics and Traumatology, Iuliu Hatieganu University of Medicine and Pharmacy, 47 General Traian Mosoiu Street, RO-400132 Cluj-Napoca, Romania

³Academy of Romanian Scientists, 3 Ilfov Street, RO-050044, Bucharest, Romania

^*Corresponding author: Maria Tomoaia-Cotisel, mcotisel@gmail.com

Abstract. There is an increasing demand for new materials in orthopedics, biomaterials that can stimulate osseointegration and vascularization, either repairing damaged tissue or producing new one. Currently, the forsterite (FS, Mg₂SiO₄) is actively researched in regards to bone tissue engineering due to its biocompatibility and high bioactivity. The present review focuses on summarizing the research regarding the in vitro (from apatite formation in simulated body fluid, SBF, to cells) and in vivo studies on forsterite.

Keywords: forsterite, orthopedic implants, in vitro effect, in vivo action

DOI    https://doi.org/10.56082/annalsarscibio.2022.1.167

Abstract Article Volume 11 No 1 2022